在心力衰竭的老年人中,疼痛感觉和肠道微生物群概况
Jie Chen1,2,3, Zequan Wang3, Angela Starkweather4
1Florida State University, College of Nursing, Tallahassee, FL, USA.
Interdisciplinary nursing research
|August 30, 2023
概括
患有心力衰竭 (HF) 的老年人由于肠道微生物群的变化而经历了更多的疼痛和改变的感觉. 这些因素可以作为HF患者疼痛的生物标志物.
科学领域:
- 老年学是一门学科.
- 心脏病学 心脏病学
- 微生物学 微生物学
背景情况:
- 心力衰竭 (HF) 患者经常报告严重的疼痛和改变的疼痛感觉,但潜在的机制仍然不清楚.
- 在患有高血压的老年人中识别疼痛生物标志物对于个性化疼痛管理至关重要.
- 这项研究调查了老年人的疼痛感觉,肠道微生物群和症状,有或没有HF.
研究的目的:
- 为了比较疼痛感觉,肠道微生物群和老年人与没有HF的症状概况.
- 探索疼痛,肠道微生物群多样性和HF患者的症状之间的关联.
- 为了确定潜在的生物标志物疼痛的老年人心力衰竭.
主要方法:
- 招募了20名患有HF的老年人和年龄相匹配的健康对照 (HC).
- 利用定量感官测试和条件疼痛调制来评估疼痛值和调制.
- 通过16S rRNA测序分析了肠道微生物组成,并测量了自我报告的疼痛和症状.
主要成果:
- 与HC相比,HF受试者报告的疼痛强度,睡眠障碍,疲劳,焦虑和抑郁程度更高.
- HF受试者表现出改变的有条件疼痛调节和肠道微生物群组成,心肌收缩途径减少.
- 定量感官测试和肠道微生物群多样性与HF患者的疼痛和症状有显著的关联.
结论:
- 患有HF的老年人经历了更大的疼痛和与独特的肠道微生物群特征相关的感官感知变化.
- 疼痛感觉和肠道微生物群组成显示出作为HF疼痛和症状的生物标志物的潜力.
- 需要对更大的队列进行进一步的研究,以验证这些发现及其临床影响.
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