左束支部区域节奏与右心室节奏在患有心房静脉阻塞的患者:一个观察性队列研究
Zhongxiu Chen1, Yuanning Xu1, Lingyun Jiang1
1Department of Cardiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Cardiovascular therapeutics
|August 30, 2023
概括
左捆支部区域节奏 (LBBAP) 是对心房阻塞 (AVB) 患者的右心室节奏 (RVP) 的安全有效替代方案. LBBAP减少死亡率,心力衰竭住院,并改善左心室同步.
科学领域:
- 心脏病学 心脏病学
- 电力生理学 电力生理学
- 医疗器械 医疗器械
背景情况:
- 房阻塞 (AVB) 需要植入心脏起器.
- 传统的右心室节奏 (RVP) 可以导致心室失调和不良结果.
- 左捆分支区域步调 (LBBAP) 是一种新兴的替代步调策略.
研究的目的:
- 在AVB患者中比较LBBAP与RVP的安全性和有效性.
- 评估LBBAP对死亡率,心力衰竭住院和心脏功能的影响.
主要方法:
- 在2018年至2021年期间,对903名AVB患者进行了心脏起器植入 (LBBAP或RVP) 的观察队列研究.
- 主要结局:综合所有原因死亡率,衰竭或心力衰竭住院治疗 (HFH).
- 二次结局:周围手术并发症,心脏病死亡,昏迷. 左心室 (LV) 功能分析的倾向分数匹配.
主要成果:
- LBBAP与初级复合结果 (OR 0.48,p=0.009) 的风险明显降低,包括所有原因死亡率和高血压高血压死亡率的降低.
- 与RVP相比,LBBAP显示出与RVP相比,复发性不明原因的风险较低的趋势.
- 在LBBAP组中,LV缩失调指数明显较低 (5.68 ± 1.92%) 与RVP (6.50 ± 2.28%,p=0.012).
结论:
- 对于AVB患者来说,LBBAP是一种可行且有效的节奏策略,在减少重大不良事件方面表现优于RVP.
- LBBAP改善了LV的缩同步,并可能减少的复发.
- LBBAP代表了对AVB的心脏节奏的有前途的进展.
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