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Updated: Jul 17, 2025

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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Published on: August 16, 2018

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甲基氨酸受体激活和脱敏的全调节的结构基础

Alexa Strauss, Alberto J Gonzalez-Hernandez, Joon Lee

    bioRxiv : the preprint server for biology
    |August 30, 2023
    PubMed
    概括

    阳性全调节剂 (PAMs) 和激动剂激活甲基酸盐受体 (mGluRs),而PAMs也会导致脱敏. 结构研究显示,PAMs重塑受体接口,影响信号通路.

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