估计双相情绪障碍,精神分裂症和行为特征对自杀企图的遗传责任的直接影响,使用多变量门德尔随机化方法
Brenda Cabrera-Mendoza1,2, Necla Aydin1,3, Gabriel R Fries4,5
1Department of Psychiatry, Yale School of Medicine, West Haven, CT 06516, USA.
medRxiv : the preprint server for health sciences
|August 30, 2023
概括
双相情感障碍 (BD) 和精神分裂症 (SZ) 的遗传责任增加了自杀企图 (SA) 的风险. 心理困扰和冒险等行为特征影响SA,在BD和SZ中与遗传因素有不同的独立性.
科学领域:
- 精神病学是一个精神病学.
- 遗传学 遗传学 是一个
- 流行病学 流行病学
背景情况:
- 双极性障碍 (BD) 和精神分裂症 (SZ) 与增加自杀企图 (SA) 风险有关.
- 了解SA的遗传,行为和社会经济因素的相互作用对于有效的预防至关重要.
研究的目的:
- 调查BD和SZ对SA的遗传责任对BD和SZ的因果关系.
- 探索行为特征,社会经济因素和物质使用障碍对SA的影响,以及它们与遗传倾向的关系.
主要方法:
- 采用两样本的孟德尔随机化 (MR) 分析,使用来自精神病基因组学联盟 (PGC) 和英国生物银行 (UKB) 的大规模基因组范围关联数据.
- 评估了BD和SZ对风险因素的因果影响,然后使用多变量MR评估了这些因素对SA的直接因果影响.
主要成果:
- 对BD (OR=1.24) 和SZ (OR=1.09) 的遗传负债显著增加了SA的几率.
- 心理困扰和冒险行为独立预测SZ中的SA,但是由BD调解的.
- 在考虑了SZ遗传责任后,孤独与SA的关联被取消了.
结论:
- 对BD和SZ的遗传倾向对自杀企图有直接的因果关系.
- 在自杀企图的背景下,行为特征与精神疾病的遗传风险因素发生复杂的相互作用.
- 对于那些患有精神疾病和自杀企图的基因风险较高的人来说,全面的心理健康评估至关重要.
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