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A Murine Model of Group B Streptococcus Vaginal Colonization
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胃肠道B组菌株成年人携带的决定因素
Elise S Cowley1,2, Ibrahim Zuniga Chaves1,2, Fauzia Osman3
1Department of Bacteriology, University of Wisconsin-Madison.
bioRxiv : the preprint server for biology
|August 30, 2023
概括
乙组链球菌 (GBS) 在成人的肠道中普遍存在,在威斯康星州成年人中发现了18%的载体. 增加GBS的丰度与更低的牙卫生频率和更高的铁消耗有关,这表明运输的新风险因素.
科学领域:
- 微生物学 微生物学
- 肠道微生物组研究研究
- 公共卫生 公共卫生
背景情况:
- 甲状腺链球菌 (B组链球菌,GBS) 是人类肠道中常见的一种细菌.
- 虽然已知GBS在新生儿中引起疾病,但90%的GBS死亡率发生在非怀孕的成年人中.
- 有限的数据存在于一般成年人群中的GBS倾向因素和储库.
研究的目的:
- 为了确定GBS在成年肠道微生物群中的流行率和丰度.
- 为了确定与GBS携带和成年人中的丰度相关的风险因素.
主要方法:
- 分析了754个成年人的便样本,使用qPCR检测GBS.
- 16S rRNA测序以根据GBS状态比较肠道微生物组合.
- 557个调查变量 (人口统计,饮食,健康) 的单变量和多变量分析.
主要成果:
- 18% (137/754) 的参与者在便中检测到GBS.
- GBS的丰富性与牙科检查/牙清洁的频率下降有关.
- 增加的GBS丰度与更高的铁消费频率相关.
结论:
- 在成年人的肠道中,GBS的频率与孕妇的频率相似.
- 一般成年人群中GBS携带的风险因素 (牙卫生,铁摄入量) 可能与孕妇的风险因素不同.
- 这项研究为未来研究减少携带者GBS丰富性的研究提供了基础.
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