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Updated: Jul 17, 2025

Peptide-based Identification of Functional Motifs and their Binding Partners
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Published on: June 30, 2013

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通过PROTAC介导的HIV-1 Nef降解有效地恢复细胞表面的CD4和MHC-I表达,并阻止HIV-1复制

Lori A Emert-Sedlak, Colin M Tice, Haibin Shi

    bioRxiv : the preprint server for biology
    |August 30, 2023
    PubMed
    概括

    科学家们开发了向仿真体 (PROTACs) 的蛋白质溶解来降解HIV-1 Nef蛋白,这是病毒持久性和免疫逃避的关键因素. 这种新的方法为开发针对HIV的新抗逆转录病毒疗法提供了一个有希望的策略.

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