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相关概念视频

Proteomics01:33

Proteomics

7.4K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
7.4K

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相关实验视频

Updated: Jul 17, 2025

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
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Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

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针对无标签的单个voxel蛋白质组的强大的收集和处理.

Reta Birhanu Kitata, Marija Velickovic, Zhangyang Xu

    bioRxiv : the preprint server for biology
    |August 30, 2023
    PubMed
    概括

    一种名为wcSOP的新方法可以实现稳健的单声素蛋白质组学,提供组织内蛋白质签名的空间分辨率. 这种技术允许组织微环境的详细蛋白质组映射,推进空间蛋白质组学研究.

    科学领域:

    • 蛋白质组学是指蛋白质组学
    • 生物技术是生物技术.

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  • 空间生物学 空间生物学

    • 背景情况:

    • 大量组织蛋白质组学缺乏空间分辨率,阻碍了组织微环境和异质性的分析.
    • 目前的方法无法在单个声素水平上绘制蛋白质组图,从而限制了对细胞和组织组织的理解.
    • 先进的质谱学 (MS) 提供了基因组规模的蛋白质组覆盖,但需要空间背景进行全面分析.

    结论:

    • 该 wcSOP-MS 方法可以实现高吞吐量强大的,无标签的单个 voxel 蛋白质组.
    • 这种技术为复杂组织中的蛋白质组映射提供了前所未有的空间分辨率.
    • wcSOP-MS为例行空间蛋白质组学和组织微环境的详细分析铺平了道路.