受体和捐赠者之间的差异rs4364254肝酶单核酸多态性影响在全源干细胞移植后对移植对宿主疾病的影响
Elisabetta Metafuni1, Sabrina Giammarco1, Silvia Bellesi1
1Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
肝酶 (HPSE) 基因变异 rs4364254 和 rs4693608 在异性干细胞移植后影响移植对宿主疾病 (GvHD) 风险. 献体 rs4364254 CC 基因型与更高的移植相关死亡率和更低的无移植复发存活率有关.
科学领域:
- 免疫遗传学 免疫遗传学
- 移植免疫学 移植免疫学
- 炎症性疾病的遗传学
背景情况:
- 肝酶 (HPSE) 基因是多态的,SNP rs4693608和rs4364254与HPSE水平相关.
- HPSE在炎症反应中发挥作用,这表明它与GvHD有潜在的联系.
研究的目的:
- 调查HPSE基因多态性 (rs4693608和rs4364254) 对GvHD发病率和异性干细胞移植 (HSCT) 后的结果的影响.
主要方法:
- 在228名HSCT接收者及其捐赠者中,HPSE SNPs rs4693608和rs4364254的基因定型.
- 基于SNP基因型的GvHD发病率,移植相关死亡率 (TRM) 和无移植复发生存率 (GRFS) 的分析.
主要成果:
- 在rs4364254 SNP中,接受者-捐赠者差异与II-IV级急性GvHD (aGvHD) 有关.
- 高风险的基因型组合预测增加aGvHD和中度/重度慢性GvHD (cGvHD).
- 捐赠者rs4364254 CC基因型与TRM增加和GRFS降低相关.
结论:
- HPSE rs4364254 SNP可以作为HSCT后GvHD的预测标记.
- 高水平的HPSE,可能与rs4364254CC基因型相关,可能会增强全活性T细胞的激活和迁移,从而导致GvHD.
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