启发性肌肉训练对PCD和CF患者的影响:试点研究
Michal Gur1,2, Eynav Manor1, Moneera Hanna1
1Pediatric Pulmonary Institute and CF Center, Rappaport Children's Hospital, Rambam Health Care Campus, Haifa, Israel.
Pediatric pulmonology
|August 30, 2023
概括
启发性肌肉训练 (IMT) 改善了原发性纤维功能障碍 (PCD) 和囊性纤维化 (CF) 患者的启发性肌肉力量. 这些呼吸肌肉强度的增加随着时间的推移而持续,这表明IMT是IMT.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 肺部康复治疗 肺部康复治疗
- 临床生理学 临床生理学
背景情况:
- 有效的呼吸依赖于协调的吸气和呼气肌肉功能.
- 鼓舞性肌肉训练 (IMT) 已在COPD中建立,并且在囊性纤维化 (CF) 和长期COVID-19中显示出希望.
- 没有先前的研究研究了IMT在初级状动力障碍 (PCD) 中.
研究的目的:
- 评估IMT对PCD和CF患者呼吸肌肉强度和肺功能的影响.
- 评估IMT在这些患者群体中的可行性和耐受性.
主要方法:
- 一个单一中心的试点研究涉及27名患者 (19名PCD,8名CF),年龄为18.4±9.8岁.
- 测量包括精神测量,肺清除指数 (LCI),最大吸入压力 (MIP) 和最大呼气压力 (MEP) 在基线,IMT1个月后和随访时.
- 参与者使用了POWERbreathe IMT设备.
主要成果:
- 在IMT1个月后,观察到MIP和MIP%的显著增加 (分别为p=0.015和p=0.046),随着随访持续改善.
- 较高的IMT遵守率 (≥90%) 与较大的MIP改善相关.
- 亚组分析证实了PCD患者显著的MIP和MIP%改善 (分别为p=0.026和p=0.049). 在螺旋计,MEP或LCI中没有发现任何显著的变化.
结论:
- IMT耐受性很好,并且有效地增强PCD患者的启发性肌肉力量.
- 改善的MIP的临床意义需要进一步调查.
- 需要进行更大规模的长期研究,以确定IMT对肺功能,恶化和生活质量的影响.
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