基因预测的腰围和心房的风险
Wenting Wang1,2, Jiang-Shan Tan3, Jingyang Wang3
1Department of Cardiopulmonary Bypass, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
Chinese medical journal
|August 30, 2023
概括
高腰围 (WC) 增加了心房动 (AF) 的风险. 减少WC可能有助于预防AF. 这项研究使用了门德尔的随机化来研究WC和AF之间的因果关系.
科学领域:
- 心脏病学 心脏病学
- 遗传学 遗传学 是一个
- 公共卫生 公共卫生
背景情况:
- 观察性研究表明,腰围 (WC) 和心房动 (AF) 之间存在关联.
- 因果推断受到观测数据中的潜在混因素的限制.
- 在AF中WC的因果作用需要进一步调查.
研究的目的:
- 调查腰围和心房动之间的因果关系.
- 用两个样本的门德尔随机化 (MR) 分析来进行强大的因果推理.
主要方法:
- 采用了两个样本的孟德尔随机化 (MR) 设计.
- 使用了WC (42个SNP) 和AF (55,114例,482,295对照) 的全基因组关联研究 (GWAS) 数据.
- 应用逆方差加权 (IVW),MR-Egger和加权中位数回归方法进行分析.
主要成果:
- 所有三种MR方法都表明高WC和AF之间存在积极的因果关系.
- 高的WC与增加的AF风险有关 (IVW OR = 1.43,P = 2.51 × 10−13).
- MR-Egger和加权中位数分析支持了这些发现,没有证据表明有定向的向性.
结论:
- 更大的腰围与心房动的风险增加有关.
- 旨在减少WC的干预措施可能对AF预防有益.
- 研究结果支持WC作为AF的可修改风险因素.
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