转移素受体水平及其罕见变体与人类肥胖症有关
Jin Qiu1, Zhiyin Zhang2, Yepeng Hu3
1Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.
Journal of diabetes
|August 30, 2023
概括
降低的转移林受体 (TFRC) 水平和一种罕见的TFRC变体与人类肥胖有关. 这表明TFRC在脂肪生物学和能量平衡中发挥作用,影响身体质量.
科学领域:
- 代谢研究的研究.
- 肥胖研究的研究.
- 线粒体功能 线粒体功能
背景情况:
- 铁平衡对于线粒体呼吸链功能和能量平衡至关重要.
- 转激素受体 (TFRC) 调解铁的吸收,并与棕色脂肪的发展有关.
- TFRC与人类肥胖之间的关联仍然未被探索.
研究的目的:
- 研究转移林受体 (TFRC) 水平和遗传变异与人类肥胖之间的关系.
- 评估TFRC在脂肪组织中的作用及其与肥胖指标的相关性.
主要方法:
- 病例对照研究分析肥胖和瘦人群的脂肪活检.
- 异构体测序和遗传评估,包括整个异构体测序.
- 在脂肪组织中测量TFRC水平,并对TFRC变体进行结构分析.
主要成果:
- 在色脂肪组织中,TFRC水平升高,但在超重患者中降低.
- TFRC水平与体重指数负相关,与解蛋白积极相关 1.
- 一种罕见的TFRC变体 (p.I337V) 显示蛋白质稳定性受损,并且在肥胖的人群中倾向于丰富.
结论:
- 降低TFRC水平与人类肥胖有关.
- 具有受损蛋白质稳定性的TFRC变异p.I337V与肥胖有关.
- TFRC可能是肥胖病理生理学的潜在因素.
关键词:
这是一个TFRC.棕色基因程序 棕色基因程序遗传变异是一种遗传变异.肥胖 肥胖 肥胖 肥胖 肥胖 肥胖 肥胖 肥胖热源性脂肪细胞 (thermogenic adipocytes) 是一种热源性脂肪细胞.更多相关视频
08:34Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
Published on: June 3, 2016
15.1K
07:46Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
Published on: April 3, 2017
25.3K
相关概念视频
01:24Obesity
534
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
534
01:28The Early Endosome: Endocytosis of Transferrin
3.3K
Essential proteins such as insulin or low-density lipoprotein (LDL) and micronutrients such as iron enter a eukaryotic cell through receptor-mediated endocytosis. Subsequently, the early endosomes fuse with the vesicles containing such receptor-ligand complexes and play a vital role in sorting the incoming ligands and receptors. While the ligands are either degraded inside the vesicle or released into the cytosol, their receptors are returned to the plasma membrane for further rounds of...
3.3K