在美国孕妇中探索产前检测偏好:一个离散选择实验
Jennifer Siranosian1, Celine Lewis2,3, Melissa Hill3,4
1Department of Genetics, Stanford University School of Medicine, Stanford, California, USA.
Journal of genetic counseling
|August 30, 2023
概括
孕妇更喜欢进行诊断性产前检测,特别是当结果很可能并由遗传学专家解释时. 他们也倾向于接受二次发现,尽管存在潜在的不确定性.
科学领域:
- 遗传学 遗传学 是一个
- 生殖健康 生殖健康
- 生物伦理学生物伦理学
背景情况:
- 诊断性产前检测提供了好处,但也带来了诸如不确定的结果和次要发现等挑战.
- 了解患者的偏好对于关于基因组测试的知情决策至关重要.
研究的目的:
- 确定孕妇对假设的产前基因组测试的偏好.
- 确定影响产前遗传检测选择的关键属性.
主要方法:
- 一个基于调查的离散选择实验被用于北加州的孕妇.
- 参与者根据结果的可能性,周转时间,结果解释和不确定的/次要发现的报告来评估假设测试.
- 还收集了人口统计数据和不确定性容忍度 (IUS-12规模).
主要成果:
- 绝大多数参与者更喜欢产前检测而不是没有检测 (p < 0.01).
- 获得结果的可能性更高显著增加了测试偏好 (p < 0.01).
- 报告二次发现 (p = 0.01) 和由遗传学专家 (p = 0.04) 的解释也被优先考虑.
结论:
- 孕妇更喜欢产前基因组测试,优先考虑具有结果高概率的测试和专家主导的解释.
- 对二次发现的偏好表明人们渴望获得全面的信息,即使存在潜在的不确定性.
- 研究结果可以为遗传咨询和产前诊断测试的共享决策提供信息.
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