不同的跨导管边缘对边缘装置对中枢几何学的短期影响
Sebastian Rosch1, Luise Kösser2, Christian Besler1
1Department of Cardiology Heart Center Leipzig at University of Leipzig Leipzig Germany.
Journal of the American Heart Association
|August 30, 2023
概括
帕斯卡系统显示了与MitraClip相似的短暂的 mitra (MV) 几何变化,但在一年内提供了更持久的 mitra 吐减少. 这表明PASCAL在通过导管边缘到边缘修复后可能更好地保留MV功能.
科学领域:
- 心血管医学 心血管医学
- 干预心脏病学 干预心脏病学
- 医疗器械 医疗器械
背景情况:
- 帕斯卡系统跨导管边缘到边缘修复对中枢 (MV) 解剖学的短期影响尚不清楚.
- 需要精确量化MV变化,以分析平均传导梯度的预测因素.
研究的目的:
- 为了比较PASCAL和MitraClip系统之间的短期MV解剖变化.
- 为了确定横管管边缘到边缘修复后平均传导梯度的预测因素.
- 在1年的随访中评估 mitrale 排泄减少的持久性.
主要方法:
- 包括100名接受过导管边缘到边缘修复的患者,以治疗二次 mitrale regurgitation (50个 PASCAL,50个 MitraClip).
- 期间干预的3DMV成像量化了短期的MV解剖变化.
- 单变量和多变量回归分析确定了平均传导梯度的预测因素.
- 一年后的随访数据评估了长期结果.
主要成果:
- 无论是PASCAL还是MitraClip,都显著减少了MV尺寸 (前后直径,环形周长,面积).
- 与MitraClip相比,PASCAL队伍在中期和晚期透析中保持了更大的解剖MV孔区域.
- 缩小腹筋中部解剖 MV 孔面积是两种器件平均传导梯度的独立预测因子.
- 在PASCAL队列中,将腹减轻到轻度或更小的减轻在PASCAL队列中更持久 (90%与随访时的72%.
结论:
- 帕斯卡和MitraClip在MV几何学上表现出类似的短期影响.
- 帕斯卡系统可以提供优越的维护MV功能和更持久的 mitrale 吐减少.
- 识别平均传导梯度的预测因素可能有助于未来选择用于跨导管边缘到边缘修复的设备.
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