在中间冠状动脉病变中,多个全血计衍生指数的预后值
Yuxiu Yang1, Chenxi Song1, Lei Jia1
1Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Angiology
|August 30, 2023
概括
系统性炎症反应指数 (SIRI) 是预测中级冠状动脉狭窄症患者主要不良心血管事件的关键炎症生物标志物. 斯里和AISI显示出最强的预后价值,提高风险预测超出传统模型.
科学领域:
- 心脏病学 心脏病学
- 炎症生物标志物 炎症生物标志物
- 预测分析是一种预测分析.
背景情况:
- 全血清 (CBC) 衍生指数正在成为潜在的炎症生物标志物,用于心血管疾病的结果.
- 在中级冠状动脉狭窄症患者中,这些指标的验证有限.
研究的目的:
- 评估中级冠状动脉狭窄症患者中各种CBC衍生的炎症指数的预后价值.
- 确定预测主要心血管不良事件 (MACE) 的最有效指数.
主要方法:
- 分析了1527名中级冠状动脉狭窄症患者的队列.
- 检查了中性细胞-淋巴细胞比率 (NLR),衍生的NLR,单细胞-淋巴细胞比率 (MLR),血小板-淋巴细胞比率 (PLR),全身免疫炎症指数 (SII),全身炎症反应指数 (SIRI) 和全身炎症总指数 (AISI).
- 主要终点是MACE的复合物,平均随访时间为6.11年.
主要成果:
- 系统性炎症反应指数 (SIRI) 显示出最高的预测能力,这是受体操作员特征曲线下的最大面积所证明的.
- 在多变量分析中,SIRI (HR 1.588) 和系统性炎症综合指数 (AISI) (HR 1.673) 是MACEs的显著独立预测指标.
- 这些指标的预测性能在可修改心血管风险因素负担较低的患者中得到改善,SIRI提供了最佳的增量值.
结论:
- 从CBC衍生的指数,特别是SIRI和AISI,是中等冠状动脉狭窄症患者中MACE的有价值的预后标志物.
- 与其他炎症指数和传统风险模型相比,SIRI显示出卓越的性能和增量预测价值.
- 这些发现支持SIRI在中级冠状动脉狭窄症患者的风险分层中使用.
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