对老年患者术后认知衰退的异黄和异黄的比较评估:一项前性观察试点研究
Damarla Haritha1, Soumya Sarkar2, Souvik Maitra1
1Department of Anaesthesiology, Critical Care and Pain Medicine, All India Institute of Medical Sciences, New Delhi, India.
在腹部手术后,37%的老年人出现了术后的认知功能障碍. 异氨酸和脱氨酸麻醉都显示出类似的认知障碍风险,与测试的生物标志物没有相关性.
科学领域:
- 麻醉学 麻醉学
- 神经科学是一个神经科学.
- 老年病的医生 老年病的医生
背景情况:
- 手术后认知功能障碍 (POCD) 影响了非心脏手术后的16%-62%的患者.
- 接受开放腹部手术的老年人 (60-80岁) 面临风险.
- 在这个人群中,常用的麻醉剂是isoflurane和desflurane等麻醉剂.
研究的目的:
- 为了比较接受异黄治疗的老年人中POCD的发病率,与接受开放腹部手术的desflurane进行比较.
- 调查POCD和血清生物标志物 (瘤亡因子α,粉胺β,S100) 在术后第3天之间的相关性.
主要方法:
- 40名患者 (ASA I-II) 在全身麻醉下接受了腹部开放手术,并进行了外周术.
- 认知功能在手术前和手术后的第三天被评估,使用一系列神经心理测试.
- 血清生物标志物度是在术后第3天测量.
主要成果:
- 37%的患者发生了POCD.
- 在异花和非花组中,POCD的发病率与异花相似 (风险比:0.65).
- 对特定测试 (Porteus Maze, Trail Making Test-B) 的异黄素组观察到反应时间显著增加.
结论:
- 异花和异花对老年患者在POCD发育方面具有相似的影响.
- 在POCD和术后第3天测量的血清生物标志物之间没有发现显著的相关性.
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