在患有鼻腔恶性瘤患者的基线生活质量下降的预测因素
Cara M Fleseriu1, Daniel M Beswick2, Sabrina L Maoz2
1Department of Otolaryngology-Head and Neck Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
International forum of allergy & rhinology
|August 30, 2023
概括
鼻恶性瘤显著降低生活质量 (QOL). 诸如性别,症状和瘤的解剖参与等因素,如骨底部侵蚀和周围神经侵入,比癌症分期更会对QOL产生负面影响.
科学领域:
- 在瘤学瘤学.
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 生活质量研究 研究 生命质量研究
背景情况:
- 鼻恶性瘤 (SNMs) 对患者在诊断时的生活质量 (QOL) 的影响尚不清楚.
- 经过验证的QOL仪器,如鼻腔结果测试 (SNOT-22) 和华盛顿大学生活质量测试 (UWQOL) 测量了QOL的不同方面.
- 了解治疗前的QOL因素对于SNM患者的个性化护理至关重要.
研究的目的:
- 在治疗前,在患有鼻腔恶性瘤 (SNMs) 的患者中确定与生活质量 (QOL) 降低相关的因素.
- 为多学科管理和患者咨询策略提供信息.
- 探索QOL,人口统计,瘤特征和症状之间的关系.
主要方法:
- 在多中心观测研究 (2015-2022) 中,预计将204名以前未经治疗的SNM患者纳入多中心观测研究 (2015-2022).
- 使用SNOT-22和UWQOL仪器收集基线QOL数据.
- 用多变量回归分析人口统计,并发病,组织病理,瘤参与和症状的分析,以确定与降低QOL相关的因素.
主要成果:
- 在SNM患者中,基线QOL显著降低.
- 头骨底部侵蚀与更糟糕的整体SNOT-22 QOL相关.
- 女性性别,表和工业暴露与较差的鼻科QOL有关.
- 周围神经侵入 (PNI) 与耳朵/面部质量和整体健康状况的恶化有关.
- 口腔参与和疼痛影响睡眠质量.
- 心理QOL受到部病变,头骨底部侵蚀和早期T1阶段的负面影响.
- 轨道侵蚀和PNI与较低的整体和社会QOL有关.
结论:
- 鼻恶性瘤显著损害了基线生活质量.
- QOL受性别,特定症状和解剖学瘤入侵 (例如,骨底部侵蚀,PNI, palatal参与) 而不是仅仅由T阶段的影响.
- 这些发现凸显了对SNM患者量身定制的QOL评估和管理策略的需要.
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