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生物素和益生菌补充剂在已确定的肥胖症中对组织的性作用

Lise Voland¹, Meng Yuan², Simon Lecoutre³

¹INSERM, Nutrition and obesities: systemic approach research group, Nutriomics, Sorbonne University, Paris, France.

American journal of physiology. Endocrinology and metabolism

|August 30, 2023

概括

结合果酸寡糖 (FOS) 和生物素,通过改善肠道健康和减少脂肪积累,可以对抗肥胖. 这种疗法可以增强全身能量代谢,减少关键器官的炎症.

科学领域:

代谢障碍代谢障碍代谢障碍
我们的肠道微生物组.
营养科学营养科学

背景情况:

肥胖与肠道微生物群失调和改变的B族维生素代谢有关.
组合疗法为治疗肥胖和相关疾病提供了潜力.
之前的研究表明,FOS和生物素减少了肥胖小鼠的脂肪量和高血糖症.

研究的目的:

研究FOS和生物素对全身能量代谢的影响.
在肥胖小鼠模型中分析脂肪组织转录组和组织学.
为了进一步阐明组合疗法的疗效背后的机制.

主要方法:

通过口服给肥胖小鼠提供果-寡糖 (FOS) 和生物素.
测量全身能量消耗和热量排泄.
分析与脂质运输相关的头骨基因/蛋白质表达.
组织学检查和脂肪组织和肝脏的基因/蛋白质表达分析.

主要成果:

FOS增加了热量分泌,并降低了状脂质运输基因/蛋白质的调节.
结合的FOS和生物素抑制了皮下脂肪的积累,减少了脂肪细胞的大小.
在脂肪组织和肝脏中,炎症和纤维化的标志物被降低了.

结论:

口服FOS和生物素补充剂对肥胖症中的关键代谢器官产生有益影响.
组合疗法在治疗肥胖病理生理学方面表现有前途.
对于管理肥胖及其并发性疾病的潜在翻译应用.

关键词:

脂肪组织的脂肪组织.代谢代谢代谢代谢肥胖肥胖肥胖肥胖肥胖肥胖肥胖肥胖益生菌益生菌前生物维生素维生素维生素是一种

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