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Updated: Jul 17, 2025

Method of Studying Palatal Fusion using Static Organ Culture
Published on: September 19, 2015
裂口口腔初级手术的时间表
Carrol Gamble1, Christina Persson1, Elisabeth Willadsen1
1From the University of Liverpool (C.G., R.C., E.C., L.P., P.R.W.) and Alder Hey Children's NHS Foundation Trust (S.M.), Liverpool, Royal Hospital for Sick Children (G.C., N.L.) and the University of Edinburgh (F.M.), Edinburgh, Northern and Yorkshire Regional Cleft Lip and Palate Service (S.C.) and Leeds General Infirmary (C.L.), Leeds, Cleft Care Scotland, Glasgow (L.C.), Bristol Dental Hospital, Bristol (L.A.), the University of Manchester (J.C.-S., A.E.-A., G.S., K.M., T.W., W.S.) and Manchester University NHS Foundation Trust (M.B., K.P.), Manchester, Birmingham Children's Hospital (B.F.) and Birmingham Women's and Children's NHS Foundation Trust (I.U.), Birmingham, Salisbury District Hospital, Salisbury (G.P.), Royal Victoria Infirmary, Newcastle upon Tyne (L.R., S.E.), and Oxford University Hospitals NHS Foundation Trust, Oxford (L.S.) - all in the United Kingdom; the University of Gothenburg (C.P.) and Sahlgrenska University Hospital (C.H.), Gothenburg, Uppsala University Hospital, Uppsala (M.A., E.L.), Linköping University Hospital, Linköping (P.B., A.-S.B.T.), Umeå University (K.B.) and Norrlands University Hospital (J.E.W.), Umeå, Skåne University Hospital, Malmö (K.K., M.S.), Karolinska Institutet, Solna (A.L., J.N.), and Karolinska University Hospital, Stockholm (L.R.W.) - all in Sweden; the University of Copenhagen (E.W., L.D.J.) and Copenhagen Cleft Palate Center (H.S.A., L.D.J.), Copenhagen, and the Cleft Palate Center, Aarhus (B.K.E., L.L., J.B.N.) - all in Denmark; the University of São Paulo, Bauru, Brazil (M.Z.A., A.P.F., C.G.A.B.G., H.C.M., S.H.A.P.-P., I.E.K.T., R.P.Y.); and Statped (R.A., A.K.H., M.B.K., J.L.) and Statped Sørøst (M.M.), Oslo, and Statped Vest, Bergen (N.-H.P., J.T.) - all in Norway.
在6个月的早期口腔裂口手术显著减少了5岁时的耳鼻缺陷与12个月相比. 这有利于婴儿与隔离的口腔裂的语言结果.
科学领域:
- 面外科手术 面外科手术
- 儿科耳鼻喉科 儿科耳鼻喉科
- 语音语言病理学 语音语言病理学
背景情况:
- 在患有隔离裂口的婴儿中进行初级手术的最佳时间对于长期结果仍然不清楚.
- 调查的主要领域包括语音,听力,牙和面部发育以及患者安全.
研究的目的:
- 为了比较一次性口腔裂口手术在6个月和12个月的有效性.
- 评估手术时间对喉功能,言语发育,听力和牙面部结果的影响.
主要方法:
- 在一项随机对照试验中,558名患有非综合征性隔离口腔裂的婴儿在6个月或12个月时接受手术.
- 语音和语言治疗师在5岁时通过标准化记录评估了喉功能.
- 主要结局:5岁时喉功能缺陷 (VPI) 评分≥4;次要结局包括语音,听力,牙面部发育和并发症.
主要成果:
- 与12个月小组 (15.0%) 相比,6个月小组的婴儿 (8.9%) 在5岁时体验了VPI的较少,这是统计学上显著的差异 (RR0.59,P=0.04).
- 术后并发症和严重的不良事件是罕见的,在两组之间是可比的.
- 分析了83.6%的6个月组和81.6%的12个月组的语音录音.
结论:
- 在6个月大龄的初级裂口口腔手术导致5岁时喉功能不充分的发病率较低,而12个月的手术相比.
- 这种较早的外科手术时间似乎有利于与隔离的口腔裂的婴儿的语言结果.
- 这项研究是在资源丰富的环境中进行的,由国家牙科和面研究研究所资助.

