每日使用纳尔特雷克森不会对美国陆军士兵的身体,认知或射击能力产生不利影响
Jamie T Carreno-Davidson1,2, Colleen M Castellani1,3, Joseph J Carreno4
1Military Performance Division, US Army Research Institute of Environmental Medicine, Natick, MA 01760, USA.
Military medicine
|August 30, 2023
概括
纳尔特雷克松 (一种阻断阿片类药物作用的药物) 对于健康的美国陆军士兵来说是安全的,在为期7天的试验中,它没有对身体,认知或射击表现产生负面影响.
科学领域:
- 军事医学 军事医学
- 药理学 药理学是指药理学的学科.
- 人类表现的人类表现.
背景情况:
- 评估武器化阿片类药物的预防性对策对于军事准备至关重要.
- 美国食品和药物管理局 (FDA) 批准的阿片类药物对手纳尔德有潜力,但它对健康的军人人员的影响还未得到充分研究.
- 了解纳尔德对非药物滥用士兵的影响是必要的.
研究的目的:
- 评估每日纳尔特雷克森给药对健康美国陆军士兵军事相关表现的安全性和有效性.
- 为了确定纳尔特雷克松对身体,认知和射击技能的影响.
- 在纳尔特雷克森治疗期间监测生理和生物反应.
主要方法:
- 16名现役美国陆军士兵参加了为期7天的纳尔特雷克森试验 (每天50毫克),试验前和试验后阶段.
- 参与者完成了身体,认知和射击评估.
- 监测生理和生物参数,包括睡眠,血液检查和日常检查.
主要成果:
- 纳尔特雷没有对身体表现,认知功能,射击技巧或睡眠时间产生负面影响.
- 在逻辑关系,匹配样本,数学速度/精度和空间处理方面,人们注意到认知能力的改善.
- 生物化学和血液学保持在正常范围内;一名参与者由于轻微的胃肠道副作用而退出.
结论:
- 对健康的美国陆军士兵来说,短期 (7天) 的每日纳尔特雷克松使用是安全的.
- 纳尔特雷没有影响身体,认知,射击或睡眠表现.
- 纳尔特雷克松显示出作为对策的潜力,而不会影响士兵的准备.
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