在膝关节骨关节炎中,子冠状腺骨:旁观者还是治疗目标?
Arta Kasaeian1, Frank W Roemer2,3, Elena Ghotbi1
1Musculoskeletal Radiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Skeletal radiology
|August 30, 2023
概括
脑下骨变化显著影响膝关节骨关节炎 (OA) 的进展. 先进的成像技术,包括MRI和CT,有助于评估这些变化,并评估疾病修饰性OA药物 (DMOADs) 的治疗方法.
科学领域:
- 整形外科 整形外科 整形外科
- 放射学 放射学是一门学科.
- 生物医学工程 生物医学工程
背景情况:
- 底骨在膝关节骨关节炎 (OA) 的发展和进展中至关重要.
- 底骨变化会影响关节平衡,并导致软骨损失.
- 了解底骨是开发有效的OA治疗的关键.
研究的目的:
- 审查当前和新兴的成像技术,以评估与膝关节OA相关的亚带状骨变化.
- 讨论这些技术在疾病修饰性OA药物 (DMOADs) 临床试验中的有用性.
主要方法:
- 对成像方式的叙述性审查.
- 讨论技术,包括放射学断形特征分析,圆束CT,微CT,MRI,双能X射线吸收计和PET.
- 专注于对骨髓病变进行半定量评估.
主要成果:
- 不同的成像技术提供了高分辨率的下阴道骨形态测量和密度的评估.
- 磁力共振成像被广泛用于评估骨髓病变和状纹理.
- 人工智能有助于自动化子冠状腺骨测量.
- 骨髓病变的评估对于预测骨髓炎的进展和治疗反应是有价值的.
结论:
- 新兴的成像技术为OA的发病和下丘脑骨变化提供了宝贵的见解.
- 这些方法对于评估DMOAD在临床试验中的疗效至关重要.
- 对骨髓病变的半定量评估显示出患者分层和治疗监测的前景.
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