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脑转移患者的长期存活率 - - 罕见情景的临床特征

M Hügel¹, J Stöhr¹, T Kuhnt¹

¹Department of Radiation Oncology, University of Leipzig Medical Center, Leipzig, Germany.

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]

|August 30, 2023

概括

脑转移 (BM) 患者的长期存活 (LTS) 是可以实现的,但异质的. 有效的局部治疗和现代的全身疗法对于改善这些患者的治疗结果至关重要.

科学领域:

在瘤学瘤学.
神经学神经学
辐射疗法辐射疗法

背景情况:

大脑转移 (BM) 是固体瘤管理的一个重大挑战.
在BM患者中,长期存活 (LTS) 是罕见的,但与特定的临床和治疗因素有关.
准确的预后得分对于指导治疗决策至关重要.

研究的目的:

评估从固体瘤获得LTS的BM患者的临床,治疗和预后特征.
评估特定于诊断的分级预后评估 (ds-GPA) 评分在预测LTS时的准确性.

主要方法:

在2010年至2020年期间,对1248名为BM治疗的患者进行了回顾性分析.
纳入标准:从BM诊断起至少存活3年.
收集的数据:患者,瘤和治疗特征,以及ds-GPA分数.

主要成果:

只有4.9% (61/1248) 的患者实现了LTS (≥3年).
常见的初级瘤包括肺癌 (45%),黑色素瘤 (20%) 和乳腺癌 (17.5%).
在诊断时 (27.5%),卡诺夫斯基绩效评分 (KPS) 和局部治疗 (手术+放射治疗) 与更好的预后有关.

结论:

在BM中的LTS是异质的,并且很难使用当前的得分来预测,例如ds-GPA.
有效的局部治疗和现代的全身疗法对于实现LTS至关重要.
需要进一步的研究来澄清伴随性疾病和脆弱性对LTS的影响.

关键词:

脆弱性脆弱性脆弱性立体电动辐射疗法立体电动辐射疗法系统性疗法是一种全身疗法.全脑辐射疗法全脑辐射疗法 ds-GPA的使用情况.

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