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患有早期和晚期黑色素瘤的患者的肠道微生物组
Russell G Witt1, Samuel H Cass1, Tiffaney Tran2
1Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston.
JAMA dermatology
|August 30, 2023
概括
健康个体和黑色素瘤患者之间的肠道微生物组形状不同,并且根据疾病阶段而异. 这些发现表明,肠道微生物组可能在黑色素瘤进展中发挥作用,并可能成为未来干预的目标.
科学领域:
- 微生物组研究的研究.
- 癌症免疫学 癌症免疫学
- 黑色素瘤研究研究
背景情况:
- 肠道微生物群影响免疫反应和免疫治疗在晚期黑色素瘤的疗效.
- 目前尚不清楚肠道微生物群在健康个体和黑色素瘤患者之间,或在不同黑色素瘤阶段之间有什么不同.
研究的目的:
- 描述和比较肠道微生物群的个人资料.
- 为了区分健康志愿者和黑色素瘤患者之间的个人资料 (早期阶段与晚期).
主要方法:
- 病例控制研究涉及228名参与者 (49名健康人,38名早期黑色素瘤,141名晚期黑色素瘤).
- 使用16S核糖体RNA测序分析的便样本.
- 微生物群多样性,分类学和功能概况在不同群体之间进行比较.
主要成果:
- 在黑色素瘤患者和健康对照者之间观察到便微生物群的显著差异.
- 在早期和晚期黑色素瘤患者之间确定了不同的微生物概况.
- 与对照组相比,早期黑色素瘤表现出更高的α多样性和Roseburia的丰富性.
结论:
- 在健康个体,早期黑色素瘤和晚期黑色素瘤患者中,便微生物群的概况显著不同.
- 肠道微生物组的改变可能与黑色素瘤的进展有关.
- 对肠道微生物组在黑色素瘤中的作用的进一步研究可以确定新的治疗点.
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