皮炎患者的炎症性肠病风险
Zelma C Chiesa Fuxench1, Joy Wan2, Sonia Wang1
1Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia.
JAMA dermatology
|August 30, 2023
概括
患有亚托皮性皮炎 (AD) 的人面临患炎症性肠病 (IBD) 的风险更高,风险因年龄和AD严重程度而异. 这种关联凸显了AD患者需要仔细监测的必要性.
科学领域:
- 皮肤病学和胃肠病学
- 流行病学 流行病学
- 临床研究 临床研究
背景情况:
- 关于阿托皮性皮肤炎 (AD) 和炎症性肠病 (IBD) 之间的关联存在不一致的数据.
- 很少有研究研究了AD严重程度与特定IBD亚型,如性结肠炎 (UC) 和克罗恩病 (CD) 的风险之间的联系.
研究的目的:
- 为了确定患有AD的儿童和成人新发IBD,UC和CD的风险.
- 探索AD严重程度如何影响患上这些胃肠道疾病的风险.
主要方法:
- 一项基于人口的队列研究,使用1994年至2015年的英国电子医疗记录.
- 根据年龄,实践和索引日期,将患有AD的患者与对照组进行匹配,使用治疗暴露作为AD严重程度的代理.
- 使用后勤回归来分析与对照组相比,在AD患者中发生IBD,UC和CD的风险.
主要成果:
- 患有阿兹海默症的儿童患上IBD风险增加了44%,CD风险增加了74%,随着阿兹海默症的严重程度而升级.
- 患有AD的成年人患上IBD的风险增加了34%,CD的风险增加了36%,UC的风险增加了32%,也随着AD的严重程度而增加.
- 虽然患有严重AD的儿童患UC的风险增加,但儿童患UC的总体风险并没有显著增加.
结论:
- 患有AD的儿童和成年人表现出IBD的风险增加,因年龄,AD严重程度和特定IBD亚型而有所不同.
- 这些发现表明AD和IBD之间存在显著的关联,这强调了在AD管理中考虑胃肠道健康的重要性.
- 临床医生应对阿兹海默症患者的IBD症状保持警,尤其是在考虑全身治疗时.
相关概念视频
01:30Inflammatory Bowel Disease II: Crohn's Disease
285
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
285
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
213
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
213
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
354
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
354
01:17Chronic Bowel Disorders: Introduction
485
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
485
01:23Skin Diseases and Disorders
3.9K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
3.9K
01:29Inflammatory Bowel Disease IV: Pharmacological Management
152
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
152