在不孕症治疗后,中风住院的风险
Devika Sachdev1, Rei Yamada1, Rachel Lee2
1Department of Obstetrics, Gynecology, and Reproductive Sciences, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey.
JAMA network open
|August 30, 2023
概括
不孕症治疗与在分娩后一年内入院中风的风险更高有关. 这种增加的风险,特别是出血性中风,早在产后30天就显而易见.
科学领域:
- 生殖医学 生殖医学
- 神经学 神经学
- 公共卫生 公共卫生
背景情况:
- 在美国,中风是导致怀孕相关死亡的重要原因.
- 越来越多地使用不孕症治疗方法,需要更清楚地了解它们与中风风险的关联.
- 之前关于不孕症治疗和中风风险的研究已经产生了不同的结果.
研究的目的:
- 评估接受不孕症治疗的个人因出血和缺血性中风住院的风险.
- 在不孕症治疗后,在分娩后第一年内评估中风风险.
主要方法:
- 一项基于人口的回顾性队列研究,利用全国再接收数据库 (2010-2018).
- 包括15-54岁的个体,分娩在医院和随后住院.
- 通过使用Cox比例危险回归来比较患有中风和没有治疗不孕症的患者之间的中风住院率.
主要成果:
- 不孕症治疗与产后12个月内中风住院的比率更高 (37对29每10万).
- 对中风住院的调整后危险比为1.66 (95% CI,1.17-2.35).
- 出血性中风住院的风险明显高 (调整HR,2.02) 比缺血性中风风险 (调整HR,1.55).
结论:
- 不孕症治疗与在分娩后12个月内因中风而入院的风险增加有关.
- 这种高风险早在产后30天就可观察到.
- 建议包括及时进行产后跟踪和持续长期监测中风风险.
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