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八种菲洛病毒的VP24矩阵蛋白通过抑制干扰素诱导的途径来降低天生的免疫反应

Hira Khan¹, Lav Tripathi¹, Pekka Kolehmainen¹

¹Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland.

The Journal of general virology

|August 30, 2023

概括

菲洛病毒VP24蛋白质是先天免疫反应的关键抑制剂. 大多数filovirus VP24s阻断干扰素诱导的抗病毒基因表达,除了Marburgvirus VP24这样的例外,突出了保存的免疫逃避策略.

科学领域:

病毒学病毒学
免疫学免疫学免疫学
分子生物学分子生物学

背景情况:

菲洛病毒具有一种病毒蛋白24 (VP24),可以抑制宿主天生的免疫反应.
对于抗病毒研究来说,了解VP24在不同filovirus物种中的保存功能至关重要.

研究的目的:

系统地分析九种哺乳动物的菲洛病毒VP24蛋白对干扰素 (IFN) 诱导的免疫反应的抑制作用.
研究核定位信号 (NLS) 在VP24的免疫逃避功能中的作用.

主要方法:

来自各种filoviruses (埃博拉,博姆巴利,Bundibugyo,雷斯顿,苏丹,泰森林,Lloviu,孟拉和马尔堡) 的VP24蛋白质的暂时表达.
检测IFN-α诱导的促进子激活菌病毒耐药性蛋白1 (MxA) 和干扰素诱导的跨膜蛋白3 (IFITM3).
对内源MxA蛋白表达和VP24的NLS突变的分析.

主要成果:

在九个filovirus VP24蛋白中,有八个抑制了IFN诱导的MxA和IFITM3促进体激活.
马尔堡病毒VP24是唯一缺乏抑制活性的蛋白质.
IFN诱导的MxA表达的抑制依赖于VP24NLS中的功能3 .

结论:

菲洛病毒VP24蛋白质在基因和功能上保持着抑制天生的免疫反应的能力.
大多数filovirus VP24蛋白质通过NLS-依赖机制有效地降低宿主抗病毒基因表达.
VP24在线病毒中保留的免疫逃避功能呈现出潜在的治疗点.

关键词:

如果IFITM3是IFITM3,那么它是什么?在MxAA中使用.VP24 VP24 在线视频菲洛病毒 (filovirus) 是一种病毒.这是先天免疫力.干扰子干扰子干扰子核定位信号是一个核定位信号.

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