在韩国 (2006-2016) 患有壮病的患者中抑郁症的风险:一项基于全国人口的全国性研究
Shinje Moon1, Sangmo Hong2, Kyungdo Han3
1Department of Internal Medicine, College of Medicine, Hallym University, Seoul, Republic of Korea.
European journal of endocrinology
|August 30, 2023
概括
未经治疗的壮症患者面临更高的抑郁风险,特别是在诊断后的前三年内. 对壮症的治疗似乎可以减轻这种抑郁症风险的增加.
科学领域:
- 内分泌学 在内分泌学.
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
背景情况:
- 巨症与抑郁症的患病率增加有关.
- 之前的研究由于巨病的罕见性而受到小样本的限制.
- 这项研究使用大型国家数据库调查了壮病患者的抑郁风险.
研究的目的:
- 为了确定被诊断为壮症的患者抑郁症的风险.
- 为了比较治疗和未治疗的壮病患者之间的抑郁风险.
- 为了确定特定的时间框架,在未经治疗的壮症中,抑郁症风险升高.
主要方法:
- 使用了韩国国家健康信息数据库 (NHID) 罕见不可治愈疾病登记 (2006-2016).
- 根据年龄和性别,将壮症患者与没有壮症 (1:5比) 的对照参与者匹配.
- 采用多重考克斯回归分析来评估抑郁风险.
主要成果:
- 未经治疗的壮症患者表现出明显增加的抑郁风险 (HR: 1.43,95% CI: 1.12-1.82).
- 在接受治疗的壮病患者中没有观察到抑郁症风险的增加.
- 在未接受治疗的组中,抑郁症的风险在观察的前3年显著增加 (HR: 1.829,95% CI: 1.305-2.563),随后正常化.
结论:
- 与对照组相比,未经治疗的壮症患者患抑郁症的风险更高.
- 对于未经治疗的壮病患者,建议对抑郁症进行密切监测,特别是在诊断后的最初几年.
- 这些发现支持开发查策略,以减少壮病患者的抑郁症发病率.
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