在前列腺癌初级放射治疗后,患者报告下肢胀
Lars Fokdal1,2, Martin Berg1,3, Ahmed H Zedan1
1Department of Oncology, Vejle Hospital, University Hospital of Southern Denmark, Vejle, Denmark.
Acta oncologica (Stockholm, Sweden)
|August 30, 2023
概括
二次性淋巴 (LLE) 是前列腺癌放射治疗的副作用. 高BMI显著增加LLE风险,这表明肥胖患者的康复计划.
科学领域:
- 在瘤学瘤学.
- 辐射疗法 辐射疗法
- 淋巴 edem 研究 研究 淋巴 edem 研究
背景情况:
- 前列腺癌的放射治疗可以导致二次淋巴 (LLE).
- 关于前列腺癌放射治疗后LLE患病率和风险因素的数据有限.
- 这项研究分析了患者报告的LLE和相关风险因素.
研究的目的:
- 描述治疗性放射治疗后前列腺癌患者下肢胀 (LLE) 的患病率.
- 在这个队列中确定与LLE发展相关的风险因素.
主要方法:
- 分析了302名前列腺癌患者,其中有潜在的LLE数据 (EORTC QLQ-PR25).
- 患病率和卡普兰-梅尔统计数据用于LLE分析.
- 考克斯回归分析确定了LLE的风险因素.
主要成果:
- 在15个月的中位数随访期间,LLE的总体原始发病率为16.2% ("相当") 和7.0% ("很多").
- 在放射治疗后6个月内,LLE患病率显著增加.
- 在多变量分析中,高BMI (≥30) 是唯一显著的风险因素,使LLE风险增加了三倍.
结论:
- 在前列腺癌治愈性放射治疗后,严重的LLE很少见.
- 体重指数较高的患者报告显著增加了LLE.
- 肥胖的前列腺癌患者可能受益于早期LLE检测和管理计划.
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