软机器人介导的自主适应纤维化囊形成,以改善药物输送
Rachel Beatty1,2, Keegan L Mendez3,4, Lucien H J Schreiber1
1Anatomy and Regenerative Medicine Institute (REMEDI), School of Medicine, University of Galway, Galway, Ireland.
Science robotics
|August 30, 2023
概括
这项研究引入了一种新的植入式药物输送装置,可以监测和适应纤维化囊的形成,确保持续的药物释放. 纤维感应动态软储存器 (FSDSR) 克服了对外体反应的挑战,以提高治疗效率.
科学领域:
- 生物材料科学 生物材料科学
- 医疗器械 医疗器械
- 机器人技术 机器人技术 机器人技术
背景情况:
- 外体反应,以纤维化囊形成为特征,显著限制了可植入药物输送装置的寿命和有效性.
- 这种纤维封装损害了设备的整合,并通过将设备与宿主组织隔离,导致治疗失败.
研究的目的:
- 开发一种可植入的药物输送装置,FibroSensing动态软水库 (FSDSR),能够监测纤维囊的发育,并积极抵消其影响.
- 通过软机器人启动来证明FSDSR能够保持一致的药物输送,尽管异物反应通过软机器人启动.
主要方法:
- 在动物模型中,利用电化学阻抗光谱法在FSDSR多孔膜上监测纤维囊封闭,持续7天.
- 纤维状囊的电阻与其厚度和体积的增加相关,评估原沉积和肌纤维细胞增殖.
- 验证了FSDSR的药物输送适应能力 in silico和 in vitro,使用基于传感器反的气动启动触发的甲蓝的受控释放.
主要成果:
- 纤维感应膜在检测主机设备接口的变化方面表现出高灵敏度,这表明纤维化囊形成.
- 电阻测量准确地反映了纤维化囊的物理变化.
- 通过动态调整软机器人启动来响应实时阻抗测量,实现了受控的闭环药物释放.
结论:
- 该FSDSR可以有效地感知和适应异物反应,使药物在长时间内持续递送.
- 这种适应能力具有显著的潜力,可以通过克服纤维化封装来提高可植入药物输送系统的长期疗效.
- 实时传感和动态启动是下一代可植入治疗设备的有希望的策略.
相关概念视频
01:30Modified-Release Drug Delivery Systems: Stimuli-Activated
Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
01:24Site-Targeted Drug Delivery Systems: Polymeric Carriers
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...