高系统性免疫炎症指数与中年和老年人骨质疏松症有关:一个横截面研究
Suli Zhang1,2,3, Wenyan Ni1,2,3
1Department of Operating Room, Wujin Hospital Affiliated to Jiangsu University (Wujin People's Hospital), Changzhou, Jiangsu, China.
系统性免疫炎症指数 (SII) 与老年人骨质疏松症的风险更高有关. 保持SII低于530.09可能有助于降低骨质疏松症的风险在这个人群.
科学领域:
- 老年学是一门学科.
- 免疫学 免疫学 免疫学
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 系统性免疫炎症指数 (SII) 是一种新的炎症标志物,反映了身体的免疫和炎症状态.
- 骨质疏松症是一个重大的公共卫生问题,特别是在中年和老年人群中.
研究的目的:
- 调查系统性免疫炎症指数 (SII) 与中年和老年人骨质疏松症之间的关联.
- 确定SII的最佳切断值以表明骨质疏松症风险.
主要方法:
- 利用了来自2005-2008年国家健康和营养检查调查 (NHANES) 的20497名45岁及以上的个人数据.
- 计算的SII是 (血小板数 × 中性粒细胞数) / 淋巴细胞数.
- 采用多变量逻辑回归和接收器操作特征 (ROC) 曲线分析.
主要成果:
- 总共有4,625人被分析,其中435人被诊断患有骨质疏松症.
- 患有骨质疏松症的人与没有骨质疏松症的人相比,SII水平显著更高 (p = .024).
- 后勤回归证实了增加SII三位体和骨质疏松症患病率之间的正相关性 (p < .001).
- 确定了最佳的SII截止值530.09,表明骨质疏松症.
结论:
- 较高的全身免疫炎症指数 (SII) 与中年和老年人骨质疏松症有关.
- 低于530.09的SII值可能与此人群中骨质疏松症风险降低有关.
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