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接种疫苗是避免COVID-19疾病的最有效和最好的方法
Hadi Lotfi1,2, Mina G Mazar3, Negar M H Ei3
1Leishmaniasis Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran.
Immunity, inflammation and disease
|August 30, 2023
概括
本综述总结了SARS-CoV-2疫苗策略,包括非活化,病毒载体,DNA/RNA和蛋白质子单元疫苗. 它强调了开发有效疫苗来对抗冠状病毒流行病的发展.
科学领域:
- 病毒学和免疫学 病毒学和免疫学
- 疫苗开发和技术的发展和技术.
背景情况:
- 严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 流行病需要快速开发有效的疫苗.
- 冠状病毒 (HCoV) 构成重大全球健康威胁,推动预防措施的紧急研究.
- 现有的疫苗技术旨在刺激宿主对SARS-CoV-2的免疫反应.
研究的目的:
- 提供有关SARS-CoV-2疫苗开发的当前知识的全面概述.
- 审查用于制造有效的冠状病毒疫苗的各种功能策略.
- 突出关键的疫苗候选人和他们的技术方法.
主要方法:
- 审查有关SARS-CoV-2疫苗开发的现有文献.
- 根据疫苗的功能策略进行疫苗分类 (无活化,病毒载体,DNA/RNA,蛋白质子单元).
- 在不同试验阶段识别和列出突出的候选疫苗.
主要成果:
- 目前正在使用多种疫苗平台,包括非活化病毒,病毒载体,DNA/RNA和蛋白质子单元疫苗.
- 正在开发的疫苗的具体例子包括INO-4800 (DNA),mRNA-1273和BNT162b2 (RNA),阿斯特拉泽内卡和约翰逊-詹森 (病毒载体),CoronaVac和Covaxin (无活化),以及NVX-CoV2373 (蛋白质子单元).
- 通过向病毒蛋白质,mRNA,病毒载体和蛋白质子单元疫苗通过向病毒蛋白质刺激免疫系统而不会引起疾病.
结论:
- 科学界正在积极寻求各种疫苗策略,以对抗SARS-CoV-2大流行.
- 各种疫苗类型,包括mRNA,病毒载体和蛋白质子单元,提供安全有效的诱导免疫力的手段.
- 持续的研究和开发对于全球疫苗的可访问性和根除冠状病毒至关重要.
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