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单一功能组平台的多刺激响应:二氧化碳二氧化/pH/ROS触发的货物释放在纳米载体的三级氨基

Hui Wen Yong¹, Marine Ferron², Mélanie Mecteau²

¹Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montréal, Québec H3A 0B8, Canada.

Biomacromolecules

|August 30, 2023

概括

研究人员开发了新的软纳米粒子,这些纳米粒子对多种刺激 (如二氧化碳 (CO2) 和pH值变化) 作出反应. 这些纳米颗粒有效地提供黄素,减少炎症和改善巨细胞平衡,用于增强的纳米医学应用.

科学领域:

聚合物化学聚合物化学
材料科学材料科学材料科学
纳米医学是一种纳米医学.

背景情况:

设计多刺激响应纳米粒子 (NP) 往往涉及复杂的合成和对生理条件的有限响应.
利用多个内源刺激的纳米载体在纳米医学中具有显著的潜力,用于向药物输送.

研究的目的:

构建 miktoarm 基于聚合物的纳米载体,对溶解的二氧化碳 (CO2),pH值变化,活性氧物种 (ROS) 和组合的 ROS + CO2 产生反应.
从这些对刺激有反应的纳米载体中加载和评估一种抗炎药物库尔库 (Cur) 的释放.

主要方法:

合成的miktoarm基于聚合物的纳米载体,使用单一的三级胺来刺激反应.
将黄素装入纳米载体并研究药物释放动力学.
使用THP-1巨细胞进行了体外评估,以评估抗炎作用和毒性.

主要成果:

这些纳米载体对CO2,pH,ROS和ROS+CO2刺激的反应有反应性.
在NP中的黄素封装在高度下抑制了其毒性.
与自由黄相比,含黄的NP显著抑制了白素-1β的分泌,并促进了抗炎M2巨细胞的表型.

结论:

使用三级氨基的简单设计策略可以创建多功能,多刺激响应的聚合物纳米粒子.
这些开发的纳米载体显示出针对药物输送的前景,特别是纳米医学中的抗炎应用.

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