通过代谢学数据分析,维拉特鲁姆类化合物的不同成分的抗高血压活性
Zhaoli Zhou1, Juan Chen2, Yuzi Cui1
1State key Laboratory of Antiviral Drugs, Engineering Center of Henan Province of Eucommia ulmoides Cultivation and Utilization, School of Pharmacy, Henan University, Kaifeng 475004, China.
概括
在高血压大鼠中,维拉特鲁姆类化合物,特别是成分A,有效降低血压,并保护高血压大鼠免受器官损伤. 它们的机制涉及关键的代谢途径,为高血压治疗提供了一个有希望的新途径.
科学领域:
- 药理学 药理学是指药理学的学科.
- 心血管研究研究心血管研究
- 代谢学 代谢学 代谢学
背景情况:
- 高血压影响20-30%的患者,需要新的治疗方法.
- 维拉类化物以前用于高血压,但由于副作用而停止使用.
- 维拉特鲁姆类化合物在治疗高血压的确切机制尚不清楚.
研究的目的:
- 在自发高血压大鼠 (SHRs) 中研究Veratrum类化合物的短期和长期低血压效应.
- 阐明Veratrum类化合物在高血压管理中的潜在作用机制.
主要方法:
- 将总的Veratrum化物 (V),成分A (A) 和维拉特拉胺 (M) 给SHRs.
- 评估血压,脏和心血管损伤以及关键的生化标志物 (NO,ET-1,Ang II,NE).
- 代谢分析和基因和基因组的京都百科全书 (KEGG) 途径分析.
主要成果:
- 在SHRs中,V,A和M迅速降低了血压,并减轻了器官损伤.
- 组件A证明了对抗心血管疾病的显著保护作用.
- 代谢分析确定了尼古丁酸盐和尼古丁胺胺代谢作为Veratrum类化合物诱导的低血压的主要途径.
结论:
- 成分A是一种有前途的抗高血压剂,可以降低血压和目标器官损伤.
- 抗高血压作用通过调节尼古丁酸盐和尼古丁胺胺代谢,氨酸- ангиотензин系统 (RAS) 和氧化-内多林 (NO-ET) 均质来调节.
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