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非对称的上腺:上腺瘤的性变异
Nicole Bechmann1, Mats Leif Moskopp2, Georgiana Constantinescu3
1Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.
The Journal of clinical endocrinology and metabolism
|August 30, 2023
概括
性二态性影响上腺瘤发生率. 上腺不对称,在两性观察到,在各种上腺瘤的发展中发挥作用,影响诊断和预后.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 医疗成像医学成像
背景情况:
- 两性变异显著影响癌症发病率和患者存活率.
- 及时和精确的上腺瘤诊断对于改善患者的治疗结果至关重要.
研究的目的:
- 调查性别和上腺不对称性在上腺瘤发展中的作用.
- 根据性别分析不同类型的上腺瘤的横向化模式.
主要方法:
- 一个多中心的观察性研究8037名患有上腺瘤的患者.
- 针对基因表达和激素含量的人类上腺组织 (n=20) 的多组学分析.
- 关于上腺体大小的成像研究的文献综述.
主要成果:
- 某些瘤,如上腺皮层癌 (ACC) 和乳腺红细胞瘤 (PCC),在女性中更为常见.
- 神经母细胞瘤 (NB) 和阿尔多生成腺瘤 (APA) 在女性中不那么普遍.
- 瘤的横向化有所不同,大多数瘤偏好左上腺,除了偏好右侧的PCC外. 左上腺较右大,女性上腺较男性小.
结论:
- 上腺不对称是两性上腺瘤发病的潜在因素.
- 考虑到上腺不对称性对于准确诊断上腺瘤很重要.
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