光盘和黄斑血管 perfusion 密度的变化在初级角度关闭眼镜:使用光学一致性断层扫描血管图的定量研究
1Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Shantou, China.
Ophthalmic research
|August 30, 2023
概括
光学连贯断层扫描血管学揭示了减少的血管密度在光盘和黄斑的初级角度闭眼病患者. 升高的眼内压力影响光盘 perfusion 更多的比斑点 perfusion.
科学领域:
- 眼科医生 眼科 眼科
- 医疗成像医学成像
- 玻璃眼研究研究 玻璃眼研究
背景情况:
- 主要角闭眼光眼 (PACG) 和急性主角闭眼光眼 (APAC) 是一种特征是眼内压力升高的眼光眼类型.
- 研究视网膜血管系统的变化对于了解疾病进展和诊断至关重要.
研究的目的:
- 通过光学相干断层扫描血管学 (OCTA) 来研究PACG和APAC中的视网膜血管系统变化.
- 为了评估血管密度 (VD) 变化的诊断能力,在APAC和PACG的光盘和斑点的不同部门和层中进行诊断.
主要方法:
- 这是一项涉及21名亚太地区患者,21名PACG患者和17名健康对照者的横截式观察性研究.
- 使用扫描源OCTA成像的光盘和黄斑区域;使用Image J和Matlab量化VD.
- 圆皮质视网膜神经纤维层 (cpRNFL) 厚度和质细胞复合体厚度,用光谱域OCT测量.
主要成果:
- 亚太地区的小组显示较厚的高级cpRNFL与扩散的微血管脱落;黄斑表面毛细管 (SCP) VD与对照组没有显著差异.
- PACG患者表现出全视盘和周围毛囊视膜病变的减少,以及斑点SCP和深毛囊 (DCP) 视膜病变的减少.
- 光盘血管参数显示出比斑点参数更高的诊断值;OCTA血管参数在诊断PACG时表现类似于OCT结构参数.
结论:
- 升高的眼内压力在亚太和PACG中优先影响光盘区域的血管输液,而不是黄斑区域.
- 亚太地区的眼睛显示光盘 perfusion 缺陷,同时增加了 RNFL 厚度.
- 来自OCTA的血管参数显示了与PACG的OCT结构参数相比较的诊断性能.
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