基于纳米悬浮的百洛芬微针皮肤贴片用于持续管理与多发性硬化症相关的性
Gabrielle Verana1, Akeemat O Tijani1, Ashana Puri1
1Department of Pharmaceutical Sciences, Bill Gatton College of Pharmacy, East Tennessee State University, Johnson City, TN 37614, United States.
International journal of pharmaceutics
|August 30, 2023
概括
这项研究开发了一种用于巴克洛芬 (BAC) 的新型透皮微针贴片,显著提高了皮肤透率. 这一创新为持续管理多发性硬化症性提供了一个有希望的方法.
科学领域:
- 制药科学 制药科学
- 生物材料科学 生物材料科学
- 皮肤病学 皮肤病学
背景情况:
- 巴克洛芬 (BAC) 是治疗多发性硬化症 (MS) 相关的动的主要治疗方法.
- 由于BAC的半衰期短,因此需要经常服用BAC.
- 通过皮肤传递的系统可以克服剂量限制.
研究的目的:
- 为了评估透皮微针 (MN) 贴片改善BAC皮肤透的疗效.
- 评估纳米化和MN传递对BAC透的综合影响.
- 探索一种潜在的持续交付方法,用于MS性管理.
主要方法:
- 用BAC装载的纳米悬浮MN贴片的制造和表征.
- 通过猪耳皮进行BAC透的体外评估.
- 被动扩散与MN介导输送的比较.
主要成果:
- 在72小时后,BAC溶液的被动透率为92.56±11.24μg/cm2.
- 微针介导的输送将BAC透率提高了近9倍.
- 组合纳米化和MN输送实现了1951.95±82.01μg/cm2 (p <0.05) 的透.
结论:
- 通过皮肤微针输送BAC显示出在MS中持续性管理的显著潜力.
- 纳米化BAC颗粒增加了药物负载和MN贴片的累积透.
- 这种方法可能会提高患者的服从性和MS的治疗疗效.
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