在新生儿重症监护病房的多药耐药生物在生命早期的表面殖民
Marcus Wing Choy Loe1, Kee Thai Yeo2
1Department of Neonatology, KK Women's and Children's Hospital, Singapore; Duke-NUS Medical School, Singapore.
概括
在NICU的新生儿可以获得多药耐药 (MDR) 生物 (MDROs). 包括MDR菌株在内的グラム阴性细菌是常见的殖民者,对脆弱的婴儿构成感染风险.
科学领域:
- 新生儿重症监护室 (NICU) 的研究.
- 传染病流行病学 传染病流行病学
- 微生物学和抗生素耐药性
背景情况:
- 新生儿在生命早期被微生物殖民是健康结果的关键因素.
- 新生儿重症监护室 (NICU) 是脆弱婴儿患多药耐药生物体 (MDROs) 的风险增加的环境.
- 了解NICU环境中微生物殖民的特定模式对于开发有效的感染控制策略至关重要.
研究的目的:
- 在新生儿接受新生儿重症监护室治疗的新生儿中,以多药耐药生物体 (MDROs) 来描述生命早期表面殖民的流行率和模式.
- 确定主要的细菌类型,包括MDROs,殖民新生儿的外耳表面.
- 调查表面殖民和随后的细菌病的发展之间的关联.
主要方法:
- 追溯性描述性研究设计.
- 包括培养阳性外耳表面抹布的婴儿,在入院后立即获得NICU.
- 从电子健康记录中提取临床数据,培养结果和抗生素敏感性概况.
主要成果:
- 最常见的分离物是格兰阴性细菌,主要是大肠杆菌和Klebsiella spp.
- 多重耐药生物 (MDROs) 占格拉姆阴性分离物的17.4%.
- 没有检测到抗甲基西林的黄金葡萄球菌或抗万科米辛的菌菌.
- 患有细菌病的婴儿中有很大一部分在表面培养上具有一致的细菌,其中一些分离物是MDROs.
结论:
- 格拉姆阴性细菌代表了在NICU环境中初始微生物殖民的重要组成部分.
- 耐多药性阴性细菌占殖民生物的显著比例,突出了潜在的感染源.
- 这些发现强调了监测和控制在NICU人群中グラム阴性MDRO殖民化的重要性.
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