过早或早产和注意力缺陷/多动症的风险:一项全国性队列和同胞研究
Casey Crump1, Jan Sundquist2, Kristina Sundquist2
1Departments of Family Medicine and Community Health and of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY.
Annals of epidemiology
|August 30, 2023
概括
过早和早产会增加儿童注意力缺陷/多动症障碍 (ADHD) 的风险,而不考虑共同的家庭因素. 这种风险影响男性和女性,强调出生时间对神经发育结果的重要性.
科学领域:
- 神经科学是一个神经科学.
- 儿科 儿科 儿科
- 遗传学 是一个遗传学.
背景情况:
- 注意缺陷/多动障碍 (ADHD) 是一种常见的神经发育障碍.
- 早产和早产是已知的不利神经发育结果的危险因素.
研究的目的:
- 调查早产和早产与ADHD风险之间的关联.
- 探索这种关联中的潜在的性别特异性差异.
主要方法:
- 在瑞典 (1973-2013) 进行了一项关于单子婴儿出生的大型国家队列研究.
- 婴儿幸存者在2018年之前被跟踪查看ADHD诊断和药物记录.
- 使用波桑回归和共同兄弟分析来评估风险和控制混因素.
主要成果:
- 在早产 (6.1%) 和早产 (5.2%) 中,ADHD的患病率高于全产 (4.5%).
- 过早分娩与28%的ADHD风险增加有关 (PR=1.28),过早分娩与12%的风险增加有关 (PR=1.12),男性和女性的风险相似.
- 这些关联在调整社会人口统计学,围产和共同家庭因素后仍然显著.
结论:
- 在男性和女性中,早产和早产是ADHD的独立风险因素.
- 这些发现强调了早产或早产婴儿对ADHD等神经发育挑战的脆弱性.
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