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在暴露于AFFF影响的地下水中的牛中发现了新的Per-和Polyfluoroalkyl物质

Pradeep Dewapriya¹, Sandra Nilsson¹, Sara Ghorbani Gorji¹

¹Queensland Alliance for Environmental Health Sciences (QAEHS), The University of Queensland, 20 Cornwall Street, Woolloongabba 4102 Queensland, Australia.

Environmental science & technology

|August 30, 2023

概括

污染的灭火泡使牛暴露在和多基物质 (PFAS) 中. 全血分析揭示了新的PFAS,并强调了仅研究血清时对毒理风险的低估.

科学领域:

环境化学环境化学
毒理学毒理学毒理学
分析化学分析化学

背景情况:

澳大利亚的消防训练场被水性薄膜形成泡 (AFFF) 污染了per-和多基物质 (PFAS),导致地下水和农田受到广泛污染.
这些地区的牛通过受污染的地下水暴露在复杂的PFAS混合物中.

研究的目的:

为了确定牛全血和血清暴露在受AFFF影响的地下水中的PFAS类.
在生物样本中发现新的PFAS化合物.

主要方法:

对暴露牛的整体血液 (n=4) 和血清 (n=4) 的分析.
确定了30个具有不同置信度的PFAS (1a-5a).
使用高分辨率质谱测量来选嫌疑人.

主要成果:

确定了30种PFAS,其中包括三个新化合物:FHxSA-HOPrA,甲基 () 硫 () 硫胺酸和甲基 () 硫 () 硫胺酸.
在全血和血清中检测到 perfluorohexanesulfonamido propanoic acid (FHxSA-PrA),这是一个以前未报告的生物转化中间体.
主要在全血中发现的 perfluoroalkyl sulfonamides,表明血液细胞中的积累.

结论:

对全血和血清的分析对于全面了解PFAS暴露至关重要.
目前仅关注血或血清的评估可能低估了 PFAS 暴露在哺乳动物中的毒理风险.
未来对暴露于AFFF的人群的研究应该包括全血分析,以准确评估风险.

关键词:

金融基金管理系统 (PFAS) 是一个.生物转化中间体生物转化中间体高分辨率质谱测量高分辨率质谱非目标分析非目标分析一个前体的前体.硫胺酸硫胺的使用方法整体血是什么意思?全血是什么意思?

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