对切除的III期和IV期黑色素瘤的辅助系统疗法:一个多中心的回顾性临床研究
Rodrigo Rigo1,2, Philip Q Ding3, Eugene Batuyong4
1Tom Baker Cancer Centre, Division of Medical Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
The oncologist
|August 30, 2023
概括
切除黑色素瘤的现实世界辅助系统治疗显示高复发率和显著的长期毒性,包括内分泌病变,尽管治疗. 这些发现与临床试验数据一致.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 临床研究 临床研究
背景情况:
- 辅助疗法被批准用于切除的黑色素瘤,基于改善无复发生存率.
- 对黑色素瘤辅助治疗的现实数据对于了解治疗有效性和安全性至关重要.
研究的目的:
- 介绍一项关于切除高风险黑色素瘤辅助系统治疗的现实研究的早期发现.
- 评估没有复发的生存率,并确定接受辅助治疗的患者的亚组差异.
主要方法:
- 对接受辅助全身治疗的被切除的高风险III期和IV期黑色素瘤患者的回顾性图表审查.
- 统计分析以评估无复发生存率和与治疗相关的毒性.
主要成果:
- 包括149名患者;86.5%接受了抗PD-1免疫疗法,13.4%接受了BRAF向治疗.
- 随访22.4个月的中位数,复发率为31.5%;1年和2年的无复发生存率分别为79%和62%.
- 长期毒性影响了27.4%的患者,内分泌病变和免疫相关的不良事件是常见的.
结论:
- 黑色素瘤的现实辅助系统治疗反映了临床试验实践.
- 尽管有辅助治疗,但复发率仍然很高,这强调了需要新的治疗策略.
- 长期的毒性,包括内分泌病变和慢性炎症状况,是现实世界黑色素瘤治疗的一个重大问题.
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