对于高度侵略性的神经内分泌前列腺癌的二线全身疗法
Naohiro Fujimoto1, Yuto Tsubonuma2, Yujiro Nagata2
1Department of Urology, University of Occupational and Environmental Health, Kitakyushu, Japan; n-fuji@med.uoeh-u.ac.jp.
Anticancer research
|August 30, 2023
概括
对神经内分泌前列腺癌 (NEPC) 的二线治疗显示出有限的疗效,短暂的无进展生存期. 包括PARP抑制剂在内的新疗法正在对这种侵袭性癌症进行研究.
科学领域:
- 在瘤学瘤学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 癌症研究 癌症研究
背景情况:
- 神经内分泌前列腺癌 (NEPC) 是一种侵略性的恶性瘤,通常是新发的,或者是割耐药的前列腺癌.
- 基于的第一线化疗提供了初始的疗效,但由于有限的反应持续时间和缺乏成熟的二线治疗,随后出现了重大临床挑战.
研究的目的:
- 审查目前神经内分泌前列腺癌的二线治疗选择的现状.
- 评估与现有和新兴NEPC治疗方法相关的疗效和结果.
主要方法:
- 使用PubMed和Web of Science数据库进行了全面的文献搜索.
- 总共有13篇相关文章,包括前性和后性研究,被纳入了这个系统性审查.
主要成果:
- 基于的二线化疗 (乙胺或多塞) 显示出不良结果,无进展生存时间为3个月或更短.
- 像阿姆鲁比辛和伊利诺特干这样的药物显示出适度的疗效,反应持续时间小于6个月.
- 聚 (ADP-ribose) 聚合酶 (PARP) 抑制剂可能有利于具有同源重组修复基因变异的NEPC患者.
结论:
- 目前对NEPC的二线疗法提供有限的临床益处,突出了对有效治疗的未满足需求.
- 目前正在进行的临床试验正在探索新型药物,如免疫检查点抑制剂,分子向疗法和PARP抑制剂.
- 预计NEPC的识别和活检的增加将增加患者人数,强调进一步研究和开发创新的治疗策略的必要性.
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