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在胃切除术后患有胃癌的老年患者中患有缩症的危险因素
Hironori Iwasaki1, Erina Haraguchi2, Takafumi Ihashi2
1Department of Surgery, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan hiwasaki0519@gmail.com.
Anticancer research
|August 30, 2023
概括
开放性胃切除术增加了老年胃癌患者骨肌损失的风险. 腹腔镜手术可能有助于在胃切除术后保持肌肉质量,改善胃癌老年人的结果.
科学领域:
- 老年医学 老年医学
- 手术瘤学手术瘤学
- 肌肉生理学 肌肉生理学
背景情况:
- 萨尔科佩尼亚是一种普遍的肌肉疾病,增加了跌倒,骨折,残疾和死亡的风险.
- 手术后的肌肉损失会对胃肠道癌症患者的短期和长期结果以及生活质量产生负面影响.
- 老年患者的胃癌手术 (胃切除术) 可以导致显著的骨肌肉衰竭.
研究的目的:
- 在胃切除术后,在患有胃癌的老年患者中,确定骨肌肉损失的术后风险因素.
- 为了比较不同手术方法之间的肌肉消耗率.
主要方法:
- 一项病例控制研究,涉及75岁以上的患者,因为胃癌而接受激进胃切除术 (2014-2020年).
- 使用psoas肌肉指数评估的骨肌肉质量.
- 根据手术前后肌肉质量变化,患者被分为肌肉衰竭 (D) 和无衰竭 (ND) 组.
主要成果:
- 该研究包括D组的34名患者和ND组的41名患者.
- 单变量分析确定开放性胃切除术是术后肌肉损失的危险因素 (p=0.017).
- 多变量分析证实,开放式手术与肌肉衰竭有显著的关联 (p=0.032).
结论:
- 开放性胃切除术是老年胃癌患者胃切除术后的萨尔科佩尼亚进展的独立风险因素.
- 在这种患者群体中,腹腔镜手术为保持骨肌肉质量提供了一个可行的替代方案.
- 至少侵入性的方法可能对维持肌肉健康和改善老年胃癌患者的外科治疗结果至关重要.
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