评估在重症监护室输血红细胞后氧气提取速率的变化:前性观察性非干预性研究的协议
Ahmet Salih Tüzen1, Murat Aksun2, Atilla Sencan2
1Department of Anesthesiology and Reanimation, Izmir Katip Celebi University Ataturk Training and Research Hospital, Izmir, Turkey astuzen@icloud.com.
BMJ open
|August 30, 2023
概括
本研究探讨使用氧气提取率 (O2ER) 引导重症监护室 (ICU) 红细胞输血. 测量O2ER可能会改善输血决策和患者的治疗结果.
科学领域:
- 关键护理医学 关键护理医学
- 身体生理学 身体生理学
- 输血医学 输血医学
背景情况:
- 目前在ICU的红细胞输血 (RBCT) 决策依赖于血红蛋白值.
- 越来越多的人对使用组织氧化的生理指标来指导RBCT越来越感兴趣.
- 优化输血触发器至关重要,以平衡氧气输送和消耗,同时最大限度地降低输血风险.
研究的目的:
- 评估氧气提取率 (O2ER) 作为氧气供应-消费平衡的关键指标.
- 调查O2ER作为ICU患者RBCT可靠触发器的潜力.
- 分析与O2ER指导的输血决策相关的临床结果.
主要方法:
- 一项前性,单中心的观察性队列研究,涉及65名接受RBCT的ICU患者.
- 输血前后评估氧气提取率 (O2ER),动脉和中央静脉氧气含量,以及近红外光谱学.
- 主要结局:O2ER的百分比增加;次要结局:与基线O2ER相关的并发症和患者结局;90天的随访.
主要成果:
- 这项研究旨在确定O2ER百分比增加的主要结果.
- 二次结果将根据基线O2ER评估患者的并发症和总体结果.
- 分析将比较患者组之间的O2ER变化和临床结果.
结论:
- 氧气提取率 (O2ER) 是指导ICU红细胞输血的生理指标.
- 使用O2ER可能会导致更及时和适当的输血决策,可能会改善患者的治疗结果.
- 需要进一步的研究和验证,以建立O2ER作为输血触发器的标准临床实践.
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