环境PM2.5暴露可能会增加结核病复发风险
Kyung-Duk Min1, Sun-Young Kim2, Sung-Il Cho3,4
1College of Veterinary Medicine, Chungbuk National University.
Environmental health and preventive medicine
|August 30, 2023
概括
长期暴露于细颗粒物 (PM2.5) 与较高的结核病 (TB) 复发率有关. 减少空气污染可能有助于预防结核病病例.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 之前的研究探讨了环境PM2.5和结核病 (TB) 发病率,但没有区分新发病例和复发病例,也没有研究长期影响.
- 在高收入国家中,韩国面临着高结核病负担,需要对环境风险因素进行研究.
研究的目的:
- 调查长期暴露于细颗粒物 (PM2.5) 和韩国新发和复发结核病 (TB) 发病率之间的关联.
- 分析不同平均PM2.5暴露时间 (1-5年) 对结核病发病率的影响.
主要方法:
- 一项区域级生态研究分析了2015年至2019年间韩国250个地区的数据.
- 根据年龄和性别标准化的结核病发病率与PM2.5平均度的回归,使用带有时空自相关的负二项模型.
- 对结核病总病例,新发病例和复发病例进行了分层分析.
主要成果:
- 较高的长期PM2.5度与增加的结核病复发率有显著联系.
- 在PM2.5中增加10μg/m3的相对风险分别为1.218,1.260和1.473的2年,3年和5年的平均暴露.
- PM2.5和结核病复发之间的关联随着更长的暴露时间而加强.
结论:
- 长期暴露于PM2.5是肺结核复发的重要危险因素.
- 旨在减少空气污染的干预措施可能是预防和控制结核病的可行策略.
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