胆汁酸在白色脂肪组织中的新兴作用
Andreas Schmid1, Thomas Karrasch2, Andreas Schäffler2
1Basic Research Laboratory for Molecular Endocrinology, Adipocyte Biology, and Biochemistry, University of Giessen, D 35392 Giessen, Germany.
Trends in endocrinology and metabolism: TEM
|August 30, 2023
概括
胆汁酸 (BAs) 作为类固醇激素起作用,被称为胆汁酸.
科学领域:
- * 内分泌学 在内分泌学.
- * 代谢过程中的代谢.
- *生理学 *生理学
背景情况:
- *胆汁酸 (BAs) 在肝脏,肠内分泌功能,小肠和棕色脂肪组织中进行了广泛研究.
- * 周围循环BA代表了一个被低估的生理部位.
- * 系统性BAA在白色脂肪细胞上充当类固醇激素.
研究的目的:
- * 为了在脂肪细胞中提出BA特异性FXR/TGR5受体相互作用的"比洛金" (胆汁激素).
- *强调BA在调节脂肪细胞功能和相关代谢过程中的作用.
- * 探索BA信号作为肥胖相关代谢功能障碍的治疗策略.
主要方法:
- *审查和讨论关于胆酸生理和功能的现有文献.
- *专注于胆汁酸与脂肪细胞及其受体 (FXR/TGR5) 的相互作用.
- *分析胆汁酸对脂肪细胞分化,脂质代谢和炎症信号的调节作用.
主要成果:
- * 胆汁酸作为信号分子 ("胆汁酸") 通过FXR/TGR5.5影响白色脂肪细胞.
- * 胆汁酸调节脂肪细胞的关键功能:分化,脂质积累,缺氧,自和阿迪波金/细胞因子的分泌.
- * 胆酸信号影响胰岛素信号和脂肪细胞中的葡萄糖吸收.
结论:
- * 系统性胆酸作为类固醇激素 (比洛基因) 起作用,影响脂肪细胞生物学.
- *BA信号通路为脂肪炎和代谢疾病提供了潜在的治疗点.
- * 针对BA信号可能会解决胰岛素抵抗和2型糖尿病的潜在机制.
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