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量化声学参数对时间和空间化活动的影响:测量化剂量
Daniel Suarez Escudero1, Kevin J Haworth2, Curtis Genstler3
1Department of Internal Medicine, Division of Cardiovascular Health and Disease, University of Cincinnati, Cincinnati, OH, USA.
Ultrasound in medicine & biology
|August 30, 2023
概括
这项研究量化了使用EKOS导管在Definity输液期间的化活动. 声学参数会影响化剂量,使得针对治疗应用 (如声热溶解) 进行量身定制的脉冲方案.
科学领域:
- 生物医学工程 生物医学工程
- 声学物理 声学物理
- 医疗器械技术 医疗器械技术
背景情况:
- 化增强药物输送显示出治疗各种疾病的前景.
- 声高血栓溶解是一种用于深静脉血栓的应用.
- 优化化是有效的治疗剂输送的关键.
研究的目的:
- 量化化活动的空间和时间分布.
- 通过 EKOS 导管通过 Definity 检查核化化.
- 评估声学参数对化的影响.
主要方法:
- 在一个体外幻影中比较了三种无声化协议.
- 测量了峰值稀缺压力,脉冲持续时间和脉冲重复频率的效应.
- 使用被动化成像量化惯性和稳定的化,并定义了一个化剂量指标.
主要成果:
- 在整个30分钟的Definity输注中,腔持续存在.
- 较高的声压增加了惯性和稳定的洞穴剂量.
- 化剂量与脉冲重复频率和时间能量演变有复杂的关系.
结论:
- 基于能量密度的化剂量指标有效测量了声学参数的影响.
- 可以使用特定的脉冲方案来促进或抑制化类型.
- 这些发现可以为未来的研究提供信息,将空洞化剂量与声血栓抑制疗效相关联.
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