血修复使死骸幸存者成为天生的免疫调节器
Shiqi Xu1, Tyler J Yang2, Suhong Xu1
1Center for Stem Cell and Regenerative Medicine and Department of Burn and Wound Repair of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China; International Biomedicine-X Research Center of the Second Affiliated Hospital, Zhejiang University School of Medicine and the Zhejiang University-University of Edinburgh Institute, 718 East Haizhou Rd., Haining, Zhejiang 314400, China.
Seminars in cell & developmental biology
|August 30, 2023
概括
动物细胞可以在血损伤后幸存下来,甚至成为免疫调节器. 这篇评论探讨了死细胞存活,膜修复,以及由临死细胞体验触发的免疫信号.
科学领域:
- 细胞生物学 细胞生物学
- 免疫学 免疫学 免疫学
- 生物物理学的生物物理.
背景情况:
- 血膜对于动物细胞的生存至关重要;损伤可能导致致命的亡.
- 细胞有内在的机制来修复血损伤,使其能够生存.
- 幸存下来的次致命损伤可以使细胞发出信号来信号免疫反应.
研究的目的:
- 审查各种系统 (体外,C. elegans,老鼠,人类) 中死细胞存活的证据.
- 为了总结细胞机制用于等离子体膜修复.
- 通过膜修复提出一个模型来解释死亡细胞如何调节先天免疫力.
主要方法:
- 关于死细胞存活率的体外和体内研究的文献综述.
- 已知细胞膜修复通路的概述.
- 通过死亡细胞进行免疫调节的数学模型的开发.
主要成果:
- 有证据支持各种生物系统中死细胞的生存.
- 存在多种膜修复机制来维持细胞完整性.
- 临死经历可以将细胞转化为免疫激活实体.
结论:
- 膜损伤后的细胞存活是可能的,并具有重大影响.
- 膜修复是细胞生存和随后的免疫信号的关键.
- 死亡的细胞,通过修复,可以充当天生的免疫调节器,将生物效应扩展到细胞消除之外.
相关概念视频
Enlargement of the Plasma Membrane
1.9K
Cell division and enlargement are processes that require precise control. The control ensures that cell division cannot proceed unless the cell has grown to a specific size. A spherical, dividing cell requires an approximately 1.6X increase in its surface area to double its volume. The secretory pathway also has a significant role in cell membrane enlargement. Secretory vesicles that bud off from the Golgi apparatus and later fuse with the plasma membrane during exocytosis are a major source of...
1.9K
Phases of Wound Repair
6.1K
Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
6.1K
Necrosis
4.6K
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
4.6K
Overview of Regeneration and Repair
4.1K
Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
Regeneration
All animals have varying degrees of...
4.1K
Cells of the Innate Immune Response
1.7K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
1.7K
What are Membranes?
13.3K
A cell's plasma membrane demarcates the cell's borders and determines the nature of its interaction with the environment. Cells exclude certain substances, take in others, and excrete some others in controlled quantities. The plasma membrane must be flexible to allow certain cells, such as red and white blood cells, to change their shape while passing through narrow capillaries. These are the more obvious plasma membrane functions. In addition, the plasma membrane's surface carries...
13.3K


