微型软离子电源调节神经网络活动
Yujia Zhang1, Jorin Riexinger2, Xingyun Yang2
1Department of Chemistry, University of Oxford, Oxford, UK. yujia.zhang@chem.ox.ac.uk.
Nature
|August 30, 2023
概括
研究人员开发了一种微型软电源, 这种新型的离子电流发电机为微观生物刺激提供按需的能量.
科学领域:
- 生物技术
- 材料科学
- 神经科学
背景情况:
- 生物集成设备需要高效的微型电源.
- 现有的电源解决方案往往不具有生物相容性,灵活性或离子驱动.
- 在需要时储存和释放能量的微型电源是具有挑战性的.
研究的目的:
- 开发一个微型,柔软,生物相容的动力源,
- 创造一种能产生离子电流的能源,
- 为调节细胞和组织活动提供按需操作.
主要方法:
- 用脂质支持的纳米升水凝液滴网络的制造.
- 在水凝中利用内部离子梯度产生能量.
- 功率密度,能量储存和生物相容性的表征.
主要成果:
- 与以前的设计相比,开发了一种小型化的软电源,其体积减少了10^5倍.
- 实现24小时以上的能量存储,从而实现按需运行.
- 证明了功率密度增加了680倍 (约. 这样一来,
结论:
- 新型水凝液滴装置作为生物相容的离子电流源.
- 在3D神经微组织和老鼠脑部切片中成功调节了神经网络活动.
- 这种柔软的微观离子器具有融入生物的潜力.
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