男人的出生大小和血清水平的生物年龄标志物在男性
Agnieszka Żelaźniewicz1, Judyta Nowak-Kornicka2, Bogusław Pawłowski2
1Department of Human Biology, University of Wrocław, Ul. Przybyszewskiego 63, 51-148, Wrocław, Poland. agnieszka.zelazniewicz@uwr.edu.pl.
Scientific reports
|August 30, 2023
概括
出生大小并不能预测成年男性的生物衰老. 这项研究发现30-45岁健康男性的子宫内生长和关键衰老生物标志物之间没有联系,这表明产前发育可能不会影响成年衰老轨迹.
科学领域:
- 内分泌学 在内分泌学.
- 老年学是一门学科.
- 人体生理学 人体生理学
背景情况:
- 宫内生长限制 (IUGR) 与发育变化和与年龄有关的疾病风险增加有关.
- 产前发育可能会影响人类的衰老轨迹.
- 生物年龄反映了生理衰老,可以使用特定的生物标志物进行评估.
研究的目的:
- 研究成年男性出生大小和生物年龄之间的关系.
- 为了确定出生时对孕期年龄来说小是否会预测加速衰老.
- 评估产前生长与衰老生物标志物之间的关联.
主要方法:
- 研究了159名健康的,不吸烟的男性 (平均年龄35.24岁).
- 收集的出生体重和长度数据;计算的体重指数.
- 使用血清s-Klotho,hsCRP,DHEA/S和氧化应激标志物评估生物年龄.
- 对妊娠年龄,生活方式,BMI,皮质醇和进行控制.
主要成果:
- 在出生大小和s-Klotho,DHEA/S,炎症或氧化应激标志物之间没有发现显著的关系.
- 与适合妊娠年龄的男性相比,出生于怀孕年龄较小的男性在生物学年龄标志上没有差异.
- 在控制多个混因素后,这些发现仍然是一致的.
结论:
- 出生大小与30-45岁的富裕人口中男性的衰老生物标志物无关.
- 在这个群体中,子宫内生长似乎不能预测生物衰老.
- 可能需要进一步的研究来探索其他种群或衰老标志物.
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