在缓解后的库辛综合征中心血管评估和内皮功能障碍:一项前性研究
A Hacioglu1, S T Firat1, A S Caglar1
1Department of Endocrinology, Erciyes University Medical School, Kayseri, Turkey.
Journal of endocrinological investigation
|August 30, 2023
概括
库希综合征缓解改善了心血管健康,但像ADMA和ET-1这样的内皮功能障碍标志物不能可靠地反映这些变化. 代谢改善与缓解后的所有炎症标志物没有直接相关.
科学领域:
- 内分泌学 在内分泌学.
- 心血管医学 心血管医学
- 内部医学 内部医学
背景情况:
- 库希综合征 (CS) 与显著的心血管风险有关.
- 在CS患者中,内皮和心血管功能经常受到损害.
- 评估缓解后的变化对于了解长期结果至关重要.
研究的目的:
- 评估CS患者在缓解之前和之后的内皮和心血管功能.
- 评估内皮介质和促炎细胞因子的变化.
- 确定CS缓解对心血管健康的影响.
主要方法:
- 招募了新诊断的内源性CS的成年患者.
- 评估包括代谢参数 (BMI,葡萄糖,脂质),心血管评估 (血压监测,CIMT,口,心声学) 和生物标志物分析 (ADMA,ET-1,IL-1β,TNF-α).
- 为了进行比较,包括一个年龄,性别和BMI匹配的对照组.
主要成果:
- 与对照人群相比,CS患者的平均动脉压 (MAP) 和心动脉内膜介质厚度 (CIMT) 较高,流量介导扩张 (FMD) 和 mitra E/A比率较低.
- 在缓解后,BMI,脂质,禁食葡萄糖,MAP和CIMT的显著改善.
- 然而,口并没有改善,内甲素-1 (ET-1) 水平在缓解后增加,而ADMA,IL-1β和TNF-α保持不变.
结论:
- 库辛综合征的缓解导致某些心血管参数的改善.
- 不对称的二甲基氨酸 (ADMA) 和内皮蛋白-1 (ET-1) 并不是CS内皮功能障碍的始终可靠的标记物.
- 缓解后的代谢改善不一定转化为TNF-α和IL-1β血清度的变化.
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