从出生到青春期,同类氨酸,ADMA和SDMA血水平的发育动态
Florence Baach1, Boglarka Meyer1, Jun Oh1
1Department of Paediatrics, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
Amino acids
|August 30, 2023
概括
这项研究表明,在患有慢性病 (CKD) 的儿童中,不对称和对称的二甲基氨基 (ADMA,SDMA) 水平升高. 这些发现凸显了监测儿童慢性病患者瓜尼迪诺化合物的重要性.
科学领域:
- 生物化学和分子生物学
- 儿科脏病学 儿科脏病学
- 心血管研究研究心血管研究
背景情况:
- 瓜尼迪诺化合物,如二甲基氨酸 (SDMA,ADMA) 和L-homoarginine (L-hArg) 可以影响L-arginine的生物可用性和氧化 (NO) 的产生.
- 较高的ADMA和SDMA,低的L-hArg,与成人心血管和脑血管不良结果有关.
- 这些瓜尼迪诺化合物的作用和水平在儿童群体中,特别是慢性病患者中,尚未得到充分证实.
研究的目的:
- 为了比较患有CKD和没有CKD的儿科患者的瓜尼迪诺化合物水平 (L-hArg,SDMA,ADMA).
- 为了研究瓜尼迪诺化合物与不同儿科组的年龄之间的关系.
- 为了确定CKD和膜过率 (GFR) 是否影响儿童中的瓜尼迪诺化合物度.
主要方法:
- 分析了57名患有CKD的儿童和141名没有CKD的儿童 (0-17岁) 的血样本.
- 使用相关性和回归分析来评估瓜尼迪诺化合物,年龄,CKD状态,GFR和肌素之间的关系.
- 使用了包括Kruskal-Wallis和Spearman相关性在内的统计测试.
主要成果:
- 在新生儿中观察到L-hArg,SDMA和ADMA度最高.
- 从1岁起,L-hArg水平增加,而健康儿童的SDMA和ADMA水平下降.
- 在患有CKD的儿童中,SDMA和ADMA水平显著更高,独立于GFR (平均系数分别为1.92和1.38).
- 在儿科CKD患者中,SDMA与肌素度呈现出强烈的正相关性 (Spear 0.74).
结论:
- 这项研究为所有儿科年龄组提供了全面的瓜尼迪诺化合物参考水平.
- 儿科CKD患者中SDMA和ADMA的升高表明了对NO通路的潜在干扰.
- 这些发现支持进一步调查瓜尼迪诺化合物在儿科大脑和心血管疾病中的作用.
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